Occurs with chronic use or if dietary intake of K is less.
Longer acting thiazide causes more loss of K than shorter acting (intermittent compensatory replenishment) furosemide.
Prevention/treatment– high intake of K, supplement KCL, use K sparing diuretic.
Only with loop diuretics in presence of renal insufficiency.
Competition with uric acid in PCT for secretion.
Less with low dose thiazides
Increase the risk of ventricular arrhythmia associated with digitalis.
Seen with thiazides only.
Thiazides causes decrease in blood volume which leads to reduction in GFR.
Nausea, vomiting, diarrhoea.
Dehydration and marked fall in BP
Seen with vigorous diuresis in CHF patient.
Mostly seen with loop diuretics.