AIM : Oxidation of Acetyl CoA to CO2 and H20. Also connectiong almost all individual metabolic pathways.
FUNCTION: Generates high amount of NADH/FADH2 that act as fuel for ATP synthesis in ETC.
REQUIREMENT: Aerobic conditions only (NADH and FADH2 can be regenerated in ETC only in presence of oxygen)
REACTIONS IN KREB’S CYCLE
(Citrate is Kreb’sStarting Substrate ForMaking Oxaloacetate)
So — citrateSynthetase
Dance —isocitrate Dehydrogenase
Devon — alpha-ketoglutarate Dehydrogenase
Sipped — Succinyl-CoASynthetase
Down — Succinate Dehydrogenase
Drinks — malate dehydrogenase
Regulation of TCA:
Availability of ADP is also one of the regulating factors.
Krebs cycle is both catabolic and anabolic in nature , hence regarded as amphibolic
Reactions associated are:
- Oxaloacetate →Synthesis of Aspartate
- Alpha-Ketoglutarate → Synthesis of Glutamate
- Succinyl CoA → Synthesis of Porphyrins and Heme
- Mitochondrial Citrate →cytoplasm → cleaved to get acetyl CoA → Synthesis of fatty acids , sterols , etc..
Ox — Oxaloacetate
Such As — Aspartate
Keto — alpha-Ketoglutatrate
Gluta — Glutamate
Succeded —Succinyl CoA
Merrily — Mitochondrial
Proper — Porphyrin
Blood shed — Heme
Canada — Citrate
-Shivani Indrekar (MIMER Medical College)