I have always found it difficult to remember cycles or pathways. So I thought of trying to make it easier for you to remember Ketogenesis by explaining it in the form of a story (do take a look at the pathway shown in the image to understand the story). I’m not sure if everybody would be able to relate to it, but here you go!
The story of Ketone body synthesis…..
Once, two like-minded and like-named people got married. Their names were Acetyl CoA. They named their son👶 Acetoacetyl CoA.
But Acetoacetyl CoA was not happy with his name, he wanted a manlier name, so he decided to change it to HMG CoA. He was very happy with it, but turned out that nobody was able to recognize him with such a name and he was left with no option but to change his name again. So he decided to settle for a similar version of his original name. And now, his name is Acetoacetate.
He didn’t want his kids to face these similar problems. So he adopted two kids👨👧👦 and asked them what names they preferred for themselves. The girl chose her name to be Acetone (because she was sweet and smelled like fruit) and the boy decided Beta-Hydroxybutyrate (as he is now the beta of the house 😛)
And they lived happily ever after with their perfect names! 😋
A few more important points:
Ketogenesis takes place in the liver. The enzymes for ketogenesis are present in the mitochondrial matrix. HMG CoA synthase enzyme regulates the synthesis of ketone bodies. During prolonged starvation and diabetes ketoacidosis, ketone bodies are the major fuel source for the brain.
Thank you for reading!
Don’t forget to let me know in the comments if it was helpful. 😊