PHARMACOLOGY OPEN BLOG

Thiazides

Diuretics are the drugs which causes loss of Na and water in urine. CLASSIFICATION OF DIURETICS HIGH EFFICACY DIURETICS SUPHAMOYL DERIVATIVES- furosemide, bumetanide MEDIUM EFFICACY DIURETICS THIAZIDES– hydrochlorothiazide, benzthiazide THIAZIDE LIKE– metolazone, xipamide, indapamide, clopamide WEAK DIURETICS CARBONIC ANHYDRASE INHIBITORS– acetazolamide POTASSIUM SPARING DIURETICS– Aldosterone antagonist- spironolactone Inhibitors of renal epithelial Na channel- amiloride OSMOTIC …

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Side effects of thiazides and furosemide

Hypokalaemia Occurs with chronic use or if dietary intake of K is less. Longer acting thiazide causes more loss of K than shorter acting (intermittent compensatory replenishment) furosemide. Prevention/treatment– high intake of K, supplement KCL, use K sparing diuretic. Ototoxicity Only with loop diuretics in presence of renal insufficiency. Allergy Rash, photosensitivity. Hyperuricemia Competition with …

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Antiemetic and Prokinetic drugs

– Vomiting or emesis occurs due to stimulation of vomiting centre in the lateral medullary reticular formation. – It receives input from GI mucosa, CTZ & vestibular apparatus. • Antiemetics are the drugs used to prevent or suppress vomiting. Classification :- Awesome People Had Antiemetic Drugs Successfully. 1. Anticholinergics 2. Prokinetic drugs 3. H1 antihistamines …

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Drugs for Inflammatory bowel disease (IBD)

• IBD is a chronic relapsing inflammatory disease of ileum & colon. • Two major types are – ulcerative colitis(UC) & Crohn’s disease(CrD). The drugs used in both these conditions are same, but their roles & efficacy differ. The drugs are – 1. 5- amino salicylic acid compounds (5-ASA). 2. Corticosteroids. 3. Immunosuppressants. 4. TNF …

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