Pathology open blog

Leprosy/ Hansen’s disease

Leprosy/ Hansen’s disease ETIOLOGY Leprosy is a chronic infectious disease caused by M.Leprae- an acid fast bacilli. The route of transmission is unclear but is thought to be via nasal droplet infection and contact transmission. The organism prefers cooler temperature (body surface temperature is less than core body temperature) and hence it mainly involves skin …

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Complement mediated injury

Mostly the alternate pathway of complement activation is involved. (Evidence – decreased serum C3 level and normal C1,C2 and C4). The deposits of C3 (granular pattern) is seen in glomeruli. C3NeF (Circulating anti complementary nephritic factor) is an Autoantibody (Ig) – binds to C3 convertase and stabilise it leading to its persistent activation. EPITHELIAL INJURY …

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Acute proliferative glomerulonephritis (APGN) or Post Infectious glomerulonephritis (PIGN)

Let’s first understand what it means. ACUTE– transient in nature (rarely leads to renal failure) PROLIFERATIVE– proliferation of endothelial and mesangial cells POST– 1-4 weeks after INFECTIOUS– Occurring because of infections like staphy, strept. GLOMERULONEPHRITIS– Inflammation of glomerulus. PATHOGENESIS The basic mechanism which underlies this disease is SUBEPITHELIAL immune complex deposition. So, just let’s go …

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