BIOCHEMISTRY OPEN BLOG

Radioisotopes

WHAT ARE ISOTOPES Elements with same atomic number (SAN) but different atomic weights (DAW). TYPES OF ISOTOPES There are two types of isotopes: Stable Isotopes Naturally occurring Do not emit radiations Identified and quantitated by mass spectrometry or nuclear magnetic resonance. Sometimes used in biochemical investigations.   Unstable or Radioactive Isotopes (IMP SAQ) Nucleus unstable …

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Genetic code

Central Dogma Of Protein Synthesis: (By Crick) DNA ↓ m-RNA ↓ Protein   Genetic Code: Dictionary of nucleotide base combinations which determine sequence of amino acids in proteins.   Codon:              A sequence of 3 nucleotide bases on m-RNA which                            codes for a single amino acid. E.g. AUG codes for                            methionine (Number of Codons= 4 …

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Conjugation

First, let us learn what is metabolism of xenobiotics.. Detoxification –     The series of biochemical reactions occurring in the body to convert foreign compounds to non-toxic and more easily excretable form. Xenobiotic is any foreign or strange substance to the body. Detoxification of this is called metabolism of xenobiotics. The metabolism of xenobiotics is …

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Liver Function Tests

LIVER FUNCTION TESTS What is LFT? LFTs are used for mainly 2 reasons: To confirm clinical suspicion of potential liver injury or disease. To distinguish between hepatocellular injury (hepatic jaundice) and cholestasis (post hepatic or obstructive jaundice). Classification LFTs are classified according the functions of liver: Tests based on excretory function- Measurement of bile pigments, …

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